ВЛИЯНИЕ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК НА ПОЛОВУЮ ФУНКЦИЮ У ЖЕНЩИН

Е. Г. Сазонова; Т. В. Мохорт

Авторы

Е. Г. Сазонова Городской эндокринологический диспансер
Т. В. Мохорт Белорусский государственный медицинский университет

Ключевые слова:

гормональные дисфункции, хроническая болезнь почек, почечно-заместительная терапия, аменорея, бесплодие, ановуляция, гиперпролактинемия

Аннотация

В статье изложены современные представления о гормональных дисфункциях у женщин репродуктивного периода, пре- и постменопаузы при хронической болезни почек (ХБП), включающих нарушения половой и репродуктивной функции, менструального цикла, снижение фертильности, повышение рисков невынашивания беременности при ее наступлении, а также влиянии почечно-заместительной терапии (ПЗТ) на половую и репродуктивную функции. Нарушения менстурального цикла характеризуются анаовуляторными циклами, может наблюдаться аменорея. В основе гормональных дисфункций лежит отсутствие пиков ЛГ и изменения концентрации эстрадиола в зависимости от фазы цикла, гипоэстрогенемия, гиперпролактинемия. В экспериментальных исследованиях показан нефропротективный эффект эстрогенов посредством влияния на синтез и высвобождению вазоактивных веществ, цитокинов и других факторов роста, которые ответственны за нарушение функции мезангиальных клеток, а также предотвращение действия трансформирующего фактора роста β-1 (ТФР-β-1), играющего роль в процессах гломерулосклероза.

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