РАЗРАБОТКА ВАКЦИН ДЛЯ ПРОФИЛАКТИКИ КОРОНАВИРУСНОЙ ИНФЕКЦИИ: ОТ SARS И MERS ДО COVID-19
Авторы
Ключевые слова:
коронавирусы, SARS-CoV-2, вакцина, разработка вакцинАннотация
Коронавирус тяжелого острого респираторного синдрома (SARS-CoV-2) – это новый вид коронавируса, вызывающий коронавирусную инфекцию 2019 года (COVID-19), которая стала причиной самой серьезной пандемии в текущем столетии. Учитывая высокую летальность и быстрое распространение заболевания, для подавления пандемии необходимо создание эффективной вакцины. С этой целью при тесном сотрудничестве научного сообщества, фармацевтической промышленности и правительственных организаций беспрецедентными темпами осуществляется разработка и тестирование широкого спектра вакцин. В настоящем обзоре выделены наиболее существенные в контексте создания вакцин биологические характеристики коронавирусов, а также кратко изложены ключевые выводы исследований вакцин против коронавируса тяжелого острого респираторного синдрома (SARS-CoV) и коронавируса ближневосточного респираторного синдрома (MERS-CoV) с акцентом на плюсы и минусы каждой стратегии иммунизации. На основе данных о результатах изучения вакцин против этих инфекций обсуждается текущее состояние и потенциальные сложности разработки вакцин для профилактики от COVID-19.
Оригинал статьи: Li YD, Chi WY, Su JH, et al. Coronavirus vaccine development: from SARS and MERS to COVID-19. J Biomed Sci. 2020;27(1):104. DOI: 10.1186/s12929-020-00695-2.
Статья переведена на русский язык и опубликована согласно условиям лицензии Creative Commons Attribution 4.0.
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