ПРОТИВОВИРУСНАЯ И АНТИКОАГУЛЯНТНАЯ ТЕРАПИЯ У ПОЛИМОРБИДНОГО ПАЦИЕНТА С ХРОНИЧЕСКИМ ВИРУСНЫМ ГЕПАТИТОМ С. ТАКТИКА ВЕДЕНИЯ, ОСОБЕННОСТИ МЕЖЛЕКАРСТВЕННЫХ ВЗАИМОДЕЙСТВИЙ

В. А. Воловникова; Е. Н. Зиновьева

doi:10.32415/jscientia.2018.10.02

Авторы

В. А. Воловникова Санкт-Петербургский государственный университет
Е. Н. Зиновьева Клиника ЭКСПЕРТ

https://doi.org/10.32415/jscientia.2018.10.02

Ключевые слова:

хронический вирусный гепатит С, противовирусная терапия, ингибиторы протеаз, антикоагулянты, антагонисты витамина К, протезированные клапаны сердца, коморбидный больной

Аннотация

В статье изложены современные подходы к лечению хронического вирусного гепатита С генотипа 3, проанализирована обоснованность применения антикоагулянтов при заболеваниях печени, изложены принципы применения антикоагулянтной терапии у пациентов с протезированными клапанами и ее особенности при проведении противовирусной терапии с использованием ингибиторов протеаз, рассмотрены особенности межлекарственных взаимодействий и тактика ведения полиморбидного пациента, а также особенности оценки выраженности печеночной дисфункции и прогноза при хронических заболеваниях печени и циррозах у пациентов, получающих лечение антагонистом витамина К. Представлен клинический случай применения комбинированной противовирусной терапии у пациентки с механическим протезом митрального клапана, получающей постоянную терапию антагонистами витамина К.

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