НЕАЛКОГОЛЬНАЯ ЖИРОВАЯ БОЛЕЗНЬ ПЕЧЕНИ: КОМОРБИДНОСТЬ, КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ И МЕТОДЫ ДИАГНОСТИКИ ФИБРОЗА ПЕЧЕНИ

Д. В. Маршалко; И. Ю. Пчелин; А. Н. Шишкин

Авторы

Д. В. Маршалко Санкт-Петербургский государственный университет
И. Ю. Пчелин Санкт-Петербургский государственный университет
А. Н. Шишкин Санкт-Петербургский государственный университет

Ключевые слова:

неалкогольная жировая болезнь печени, фиброз печени, стеатогепатит, цирроз печени, транзиторная эластография, шкала NFS, шкала FIB-4, биопсия печени, метаболический синдром, инсулинорезистентность

Аннотация

В статье проанализированы современные научные данные о патогенетических и клинико-эпидемиологических аспектах неалкогольной жировой болезни печени (НАЖБП), которая за последнее десятилетие вышла на первое место по распространенности среди заболеваний печени в России. Рассмотрены наиболее актуальные проблемы коморбидности при НАЖБП. Дана сравнительная характеристика различных методов диагностики фиброза печени с описанием их преимуществ и недостатков. Суммированы данные последних лет о прогностическом значении индексов, используемых для неинвазивной оценки фиброза печени при НАЖБП.

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