ГИПЕРГОМОЦИСТЕИНЕМИЯ И ДИАБЕТИЧЕСКАЯ НЕФРОПАТИЯ: ВЛИЯНИЕ ГЕНЕТИЧЕСКИХ ФАКТОРОВ, КЛИНИКО-ПАТОГЕНЕТИЧЕСКИЕ ВЗАИМОСВЯЗИ С ВОСПАЛЕНИЕМ И АНЕМИЕЙ
Ключевые слова:
гомоцистеин, метилентетрагидрофолатредуктаза, сахарный диабет, хроническая болезнь почек, диабетическая нефропатия, анемия, воспаление, полиморфизмАннотация
В работе рассмотрены патогенетические факторы и клиническое значение гипергомоцистеинемии при диабетической нефропатии. Суммированы данные о влиянии полиморфизма гена метилентетрагидрофолатредуктазы на развитие и прогрессирование поражения почек при сахарном диабете. Проанализированы взаимосвязи гипергомоцистеинемии с провоспалительными цитокинами и анемией при диабетической нефропатии. Сформулированы направления дальнейших клинических исследований.
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