ОСОБЕННОСТИ МЕТАБОЛИЧЕСКИХ НАРУШЕНИЙ У МУЖЧИН И ЖЕНЩИН С НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНЬЮ ПЕЧЕНИ

С. А. Шаабани; И. Ю. Пчелин

doi:10.32415/jscientia_2020_6_6_18-32

Авторы

С. А. Шаабани Санкт-Петербургский государственный университет https://orcid.org/0000-0001-8472-8557
И. Ю. Пчелин Санкт-Петербургский государственный университет https://orcid.org/0000-0001-8529-3890

https://doi.org/10.32415/jscientia_2020_6_6_18-32

Ключевые слова:

неалкогольная жировая болезнь печени, метаболический синдром, инсулинорезистентность, синдром поликистозных яичников, эстрогены, половые различия, гомоцистеин, лептин, мочевая кислота

Аннотация

В настоящее время неалкогольная жировая болезнь печени (НАЖБП) рассматривается как мультисистемное заболевание, ассоциированное с метаболическим синдромом. Половые различия прослеживаются как в распределении заболеваемости НАЖБП в популяции, так и в преобладании тех или иных метаболических нарушений у пациентов со стеатозом печени. В статье проанализированы современные научные данные об эпидемиологии и патогенезе заболевания, в том числе о роли половых гормонов в развитии стеатоза. Суммированы данные об основных метаболических нарушениях у пациентов с НАЖБП, обсуждаются потенциальные механизмы их взаимосвязи с гормональным статусом. Рассмотрены особенности взаимосвязи НАЖБП с синдромом поликистозных яичников у женщин. Результаты проведенного анализа данных литературы свидетельствуют о целесообразности разработки стратегий диагностики метаболических нарушений у пациентов с НАЖБП, а также рекомендаций по персонализированной терапии с учетом пола и гормонального статуса пациентов.

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